Boc-Ala-NH2 (N-(tert-Butoxycarbonyl)-L-alaninamide) is a Boc-protected derivative of L-alanine with a C-terminal amide group. It serves as a key building block in solid-phase and solution-phase peptide synthesis, where the Boc group temporarily protects the α-amino group, enabling selective deprotection with acid (e.g., TFA) and subsequent coupling to other amino acids. The amidated C-terminus is ideal for constructing peptides with bioactive C-terminal amides, such as those found in hormones and neuropeptides. Widely used in pharmaceutical manufacturing for therapeutic peptides and in research for studying protein folding, enzyme substrates, and drug discovery. Its orthogonal protection strategy ensures high purity and yield in multi-step syntheses.