Fmoc-Phe(3-Cl)-OH is widely used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS) methods. It serves as a building block for introducing chlorinated phenylalanine residues into peptide chains. This modification can enhance the peptide's stability, binding affinity, or biological activity, making it valuable in drug development and biochemical research. The Fmoc group protects the amino acid during synthesis, allowing for controlled and sequential peptide chain assembly. Its application is crucial in designing peptides for therapeutic, diagnostic, and research purposes, especially in targeting specific protein interactions or improving pharmacokinetic properties.