Z-D-Dap(Boc)-OH is a doubly protected derivative of D-2,3-diaminopropanoic acid (D-Dap), featuring a benzyloxycarbonyl (Z) protecting group on the α-amino function and a tert-butoxycarbonyl (Boc) group on the side-chain amino group. It functions as a specialized building block in peptide synthesis, enabling the selective incorporation of D-Dap residues into peptide sequences, particularly in solid-phase peptide synthesis (SPPS). The orthogonal protecting strategy allows for controlled deprotection—Z via hydrogenation and Boc via acidolysis—ensuring high precision in constructing complex peptides. This compound is vital in pharmaceutical and medicinal chemistry for developing peptide-based drugs, such as antimicrobial agents, hormones, and enzyme inhibitors, while safeguarding side-chain integrity during synthesis.