(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methyl-3-phenylpropanoic acid
≥95%
Reagent
Code: #50135
CAS Number
152436-04-9
blur_circular Chemical Specifications
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Molecular Information
Weight
401.45 g/mol
Formula
C₂₅H₂₃NO₄
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Registry Numbers
MDL Number
MFCD02259493
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Physical Properties
Boiling Point
621.2°C at 760 mmHg
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Storage & Handling
Storage
2-8°C, dry and sealed
description Product Description
This compound is the Fmoc-protected (R)-α-methyl-L-phenylalanine (Fmoc-(R)-2-methyl-3-phenylpropanoic acid), a specialized building block for solid-phase peptide synthesis (SPPS). The Fmoc group selectively protects the α-amino group, offering stability under basic coupling conditions and facile removal with mild acids (e.g., piperidine), which facilitates efficient, stepwise peptide chain assembly on resin supports. The α-methyl substitution imparts steric hindrance, enhancing proteolytic stability and conformational rigidity in peptides, ideal for peptidomimetics, drug discovery, and bioactive peptide design. Its defined (R)-chirality preserves stereochemical control throughout synthesis.
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