H-Deg-OH is widely used in the synthesis of peptides, serving as a hydrophilic spacer and building block in solid-phase peptide synthesis (SPPS). It is particularly valuable in the production of modified peptides and bioconjugates, where the diethylene glycol unit imparts flexibility, enhanced solubility, and PEG-like properties. In drug development, it plays a role in creating peptide-based therapeutics, enabling the design of molecules with improved stability, solubility, or targeting capabilities. Additionally, it is utilized in biochemical research to study protein interactions and folding mechanisms, providing insights into biological processes. Its versatility also extends to materials science, where it aids in the development of biocompatible polymers and hydrogels for medical and industrial applications.