Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of cubane-based drug candidates. Its rigid three-dimensional structure enhances metabolic stability and improves binding selectivity in bioactive molecules. Commonly employed in peptide mimetics and structure-activity relationship (SAR) studies to replace traditional aromatic or aliphatic rings. Also utilized in the preparation of Boc-protected amino cubane derivatives for solid-phase and solution-phase peptide synthesis. Its unique geometry makes it valuable in materials science for designing high-energy density compounds and thermally stable polymers.