Used as a key building block in medicinal chemistry, particularly in the design of bioactive molecules and drug candidates. Its rigid bicyclic structure helps improve metabolic stability and binding selectivity, making it valuable in the development of peptidomimetics and CNS-targeted therapeutics. Commonly employed in fragment-based drug discovery to modulate physicochemical properties such as solubility and lipophilicity. Also utilized in conjugation strategies for prodrugs and in the synthesis of novel amide-based derivatives via activation of the carboxylic acid group.