Z-Glu(OSu)-OBzl is a specialized derivative of glutamic acid used in peptide synthesis. It features a benzyloxycarbonyl (Z) protecting group on the α-amino group, a benzyl (OBzl) ester on the α-carboxylic acid, and an N-hydroxysuccinimide (OSu) active ester on the γ-carboxylic acid (side chain). This structure allows for selective activation and coupling of the side-chain carboxyl group to amines, facilitating the incorporation of glutamic acid into peptide chains with controlled side-chain reactivity. It is particularly valuable in solution-phase peptide synthesis for constructing complex peptides and in the preparation of peptide conjugates for biochemical and pharmaceutical research.