Fmoc-D-Phe(2-F)-OH is widely used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS) methods. It serves as a protected amino acid derivative, where the Fmoc (9-fluorenylmethoxycarbonyl) group acts as a temporary protecting group for the amine functionality during the synthesis process. The incorporation of the fluorine atom at the 2-position of the phenyl ring enhances the stability and reactivity of the compound, making it valuable for constructing peptides with specific structural or functional properties. This compound is especially useful in the production of bioactive peptides, peptidomimetics, and other peptide-based pharmaceuticals, where precise control over amino acid sequence and stereochemistry is critical. Its application extends to research in drug discovery, biochemistry, and materials science, where modified peptides play a key role in developing targeted therapies and advanced biomaterials.