Z-Phe-OMe is widely used in peptide synthesis as a protecting group for amino acids. It helps in the selective formation of peptide bonds by protecting the amino group during the synthesis process. This compound is particularly useful in solid-phase peptide synthesis (SPPS) where it ensures the correct sequence of amino acids is maintained. Additionally, Z-Phe-OMe is employed in the study of enzyme kinetics and mechanisms, serving as a substrate for various proteolytic enzymes. Its role in research extends to the development of new pharmaceuticals and bioactive peptides, where precise control over peptide structure is crucial.