(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-4-methoxy-4-oxobutanoic acid
97%
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description Product Description
This compound is the Fmoc-protected N-methyl-L-aspartic acid with a methyl ester on the side chain carboxylic acid, commonly used as a building block in solid-phase peptide synthesis (SPPS). It enables the incorporation of N-methylaspartic acid residues into peptides, which can affect secondary structure and biological properties. The Fmoc group provides orthogonal protection for the amine, stable under acidic conditions and readily removed by mild bases like piperidine, allowing precise stepwise assembly. The N-methyl group adds steric hindrance and modifies hydrogen bonding potential. The side chain methyl ester protects the carboxylic acid during synthesis, improves solubility in organic solvents, and can be selectively deprotected post-assembly.
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