Used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS) methodologies. It serves as a building block for incorporating modified phenylalanine residues into peptides, enhancing their stability and biological activity. The trifluoromethyl group at the para position of the phenyl ring can influence the peptide's interaction with biological targets, making it valuable in drug discovery and development. Commonly applied in the synthesis of peptide-based pharmaceuticals, where specific modifications are required to improve pharmacokinetic properties or target specificity. Also utilized in research to study peptide structure-activity relationships and to develop novel bioactive compounds.