TAPI-1 is widely used in research settings as an inhibitor of metalloproteinases, particularly tumor necrosis factor-alpha converting enzyme (TACE). By blocking TACE activity, it helps prevent the release of active TNF-α, a key mediator in inflammatory processes. This makes TAPI-1 a valuable tool in studying inflammatory diseases such as rheumatoid arthritis, sepsis, and inflammatory bowel disease. It is also used in cancer research due to the involvement of metalloproteinases in tumor progression and metastasis. Additionally, TAPI-1 supports neuroscience studies by modulating synaptic plasticity and neuronal signaling through regulation of cytokine activity. Its application remains primarily experimental, aiding in the development of targeted therapies for inflammation and cancer.