Used in medicinal chemistry as a key scaffold in the development of boron-containing drugs, particularly in proteasome inhibitors for cancer therapy. Its unique boron heterocycle structure enhances binding affinity to biological targets, improving drug potency and selectivity. Also explored in antimicrobial and antifungal agents due to its ability to interact with enzyme active sites. Shows promise in targeted covalent inhibitors where the boron atom forms reversible bonds with nucleophilic residues in proteins.