TAPI-1 is primarily used in research settings to study the role of TACE (TNF-α converting enzyme) in various biological processes. It is a selective inhibitor of TACE, which plays a crucial role in the shedding of membrane-bound proteins, including TNF-α. By inhibiting TACE, TAPI-1 helps researchers understand the mechanisms underlying inflammation, immune responses, and cell signaling pathways. This compound is particularly valuable in investigating diseases where TNF-α is implicated, such as rheumatoid arthritis, inflammatory bowel disease, and certain cancers. Its application extends to experimental models where modulating TNF-α activity is essential for exploring therapeutic interventions.