TAPI-2 is primarily used in research settings as a potent inhibitor of TACE (TNF-α converting enzyme). It plays a significant role in studying the regulation of TNF-α, a cytokine involved in inflammation and immune responses. By inhibiting TACE, TAPI-2 helps researchers understand the mechanisms of inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and sepsis. Additionally, it is utilized in cellular and molecular biology experiments to explore the signaling pathways and processes influenced by TNF-α, providing insights into potential therapeutic targets for inflammatory and autoimmune conditions.