LY-411575 isomer 1 is primarily utilized in research settings, particularly in studies focused on understanding the mechanisms of gamma-secretase inhibition. Its application is significant in the field of neuroscience, where it is used to investigate the role of gamma-secretase in the production of amyloid-beta peptides, which are implicated in the pathogenesis of Alzheimer's disease. By inhibiting gamma-secretase, this compound helps researchers explore potential therapeutic strategies for Alzheimer's and other related neurodegenerative disorders. Additionally, it is employed in cellular and molecular biology studies to dissect the Notch signaling pathway, which plays a crucial role in cell differentiation, proliferation, and apoptosis. The insights gained from these studies contribute to the development of targeted therapies for cancers and other diseases where Notch signaling is dysregulated.