LY-411575 is primarily used in research settings to study the Notch signaling pathway, which plays a critical role in cellular differentiation, proliferation, and apoptosis. It is a potent gamma-secretase inhibitor, making it a valuable tool for investigating the effects of Notch pathway inhibition in various biological processes. Additionally, by inhibiting gamma-secretase, it reduces the production of amyloid-beta peptides, which is relevant for research on Alzheimer's disease and amyloid-related neurodegenerative conditions. In cancer research, LY-411575 is employed to explore its potential in suppressing tumor growth, as aberrant Notch signaling is often implicated in oncogenesis. It is also used in neuroscience studies to examine the role of Notch in neural development and neurodegenerative diseases. Its ability to modulate Notch signaling makes it relevant in stem cell research, where it helps in understanding cell fate decisions and differentiation mechanisms.