Dibenzazepine (YO-01027) is primarily utilized in research settings as a potent and selective gamma-secretase inhibitor. It is extensively studied for its role in modulating the Notch signaling pathway, which is crucial in cellular differentiation, proliferation, and apoptosis. This compound is particularly valuable in cancer research, where it helps in understanding the mechanisms of tumor growth and progression by inhibiting Notch signaling, which is often dysregulated in various cancers. Additionally, it is used in neuroscience research to explore its effects on neurodegenerative diseases, as gamma-secretase is involved in the production of amyloid-beta peptides, which are implicated in Alzheimer's disease. Its application extends to developmental biology studies, where it aids in investigating the role of Notch signaling in embryonic development and tissue homeostasis.