Used in targeted protein degradation technologies, particularly in the development of PROTACs (Proteolysis Targeting Chimeras). It functions as a linker component that connects a target protein binder to an E3 ubiquitin ligase recruiter, enabling the ubiquitination and subsequent degradation of disease-related proteins. Its structure allows for optimal spacing and orientation between the two functional moieties, enhancing degradation efficiency. Commonly applied in research for oncology, neurodegenerative diseases, and inflammatory conditions where selective protein knockdown is desired. Also utilized in optimizing pharmacokinetic properties and cellular permeability of degrader molecules.