4-Chloro-2-(2,6-dioxopiperidin-3-yl)-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione
98%
Reagent
Code: #162882
CAS Number
2154357-70-5
blur_circular Chemical Specifications
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Molecular Information
Weight
293.66 g/mol
Formula
C₁₂H₈ClN₃O₄
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Storage & Handling
Storage
2-8°C
description Product Description
Used primarily in the pharmaceutical industry as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. It plays a critical role in the development of immunomodulatory drugs for treating hematological cancers such as multiple myeloma and myelodysplastic syndromes. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins. Due to its reactivity and specificity, it is also employed in research settings for designing novel proteolysis-targeting chimeras (PROTACs) and molecular glues. Handling requires strict controls due to its potent biological activity and potential toxicity.
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