5-chloro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
98%
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description Product Description
Used primarily as a key intermediate in the synthesis of immunomodulatory drugs, particularly in the development of cereblon E3 ligase modulators. It plays a critical role in the production of targeted protein degradation therapeutics, including analogs of lenalidomide and pomalidomide. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins, making it valuable in oncology research, especially for hematological cancers like multiple myeloma and myelodysplastic syndromes. Also employed in the preparation of PROTACs (proteolysis-targeting chimeras) due to its ability to recruit E3 ubiquitin ligase.
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| Test Parameter | Specification |
|---|---|
| Appearance | Gray white solid |
| Purity (%) | 97.5-100% |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
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