4-bromo-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione

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Reagent Code: #155590
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CAS Number 2851889-86-4

science Other reagents with same CAS 2851889-86-4

blur_circular Chemical Specifications

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Weight 355.12 g/mol
Formula C₁₃H₈BrFN₂O₄
inventory_2 Storage & Handling
Storage 2-8°C

description Product Description

Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, making it valuable in developing PROTACs (proteolysis-targeting chimeras) for cancer therapy and inflammatory diseases. The bromo and fluoro substituents allow further functionalization via cross-coupling reactions, facilitating the creation of diverse compound libraries for drug discovery. Also employed in studies exploring ubiquitin-proteasome system modulation due to its ability to recruit specific proteins for degradation.

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inventory 250mg
10-20 days ฿24,630.00

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4-bromo-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione
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Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, making it valuable in developing PROTACs (proteolysis-targeting chimeras) for cancer therapy and inflammatory diseases. The bromo and fluoro substituents allow further functionalization via cross-coupling reactions, facilitating the creation of diverse compound libraries for drug discovery. Also emp

Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, making it valuable in developing PROTACs (proteolysis-targeting chimeras) for cancer therapy and inflammatory diseases. The bromo and fluoro substituents allow further functionalization via cross-coupling reactions, facilitating the creation of diverse compound libraries for drug discovery. Also employed in studies exploring ubiquitin-proteasome system modulation due to its ability to recruit specific proteins for degradation.

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