4-bromo-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione
97%
Reagent
Code: #155590
CAS Number
2851889-86-4
blur_circular Chemical Specifications
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Molecular Information
Weight
355.12 g/mol
Formula
C₁₃H₈BrFN₂O₄
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Storage & Handling
Storage
2-8°C
description Product Description
Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, making it valuable in developing PROTACs (proteolysis-targeting chimeras) for cancer therapy and inflammatory diseases. The bromo and fluoro substituents allow further functionalization via cross-coupling reactions, facilitating the creation of diverse compound libraries for drug discovery. Also employed in studies exploring ubiquitin-proteasome system modulation due to its ability to recruit specific proteins for degradation.
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