3-(4-Bromo-1-oxoisoindolin-2-yl)-1-methylpiperidine-2,6-dione
97%
Reagent
Code: #151434
CAS Number
2093386-30-0
blur_circular Chemical Specifications
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Molecular Information
Weight
337.17 g/mol
Formula
C₁₄H₁₃BrN₂O₃
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Storage & Handling
Storage
Room temperature, seal, dry
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, making it valuable in developing PROTACs (proteolysis-targeting chimeras) for cancer and inflammatory diseases. The compound's bromo and isoindolinone groups facilitate conjugation with target-binding ligands, enhancing degradation of disease-related proteins. Also explored in medicinal chemistry for optimizing pharmacokinetic properties in small molecule therapeutics.
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