3-(7-Bromo-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
98%
Reagent
Code: #149966
CAS Number
2438243-28-6
blur_circular Chemical Specifications
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Molecular Information
Weight
341.13 g/mol
Formula
C₁₃H₁₀BrFN₂O₃
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Storage & Handling
Storage
2-8°C
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, making it valuable in developing PROTACs (proteolysis-targeting chimeras) for cancer and inflammatory diseases. The bromo and fluoro substituents allow further functionalization via cross-coupling reactions, facilitating the creation of diverse compound libraries for drug discovery. Also investigated for optimizing pharmacokinetic properties in preclinical candidates due to its favorable solubility and stability profile.
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