4-Bromo-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
98%
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Used primarily as a key intermediate in the synthesis of immunomodulatory drugs, particularly in the development of cereblon E3 ligase modulators. It plays a critical role in targeted protein degradation therapies, including the production of PROTACs (proteolysis-targeting chimeras) and molecular glues. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins. This makes it valuable in oncology research, especially in hematological malignancies such as multiple myeloma and myelodysplastic syndromes. Also utilized in medicinal chemistry for structure-activity relationship studies to optimize drug potency and selectivity.
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