3-(6-Bromo-5-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione

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Reagent Code: #140682
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CAS Number 2438237-48-8

science Other reagents with same CAS 2438237-48-8

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 353.17 g/mol
Formula C₁₄H₁₃BrN₂O₄
inventory_2 Storage & Handling
Storage 2-8°C

description Product Description

Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon (CRBN)-based E3 ligase modulators. Its structural features enable selective binding to CRBN, facilitating the ubiquitination and subsequent degradation of disease-related proteins. This makes it valuable in developing treatments for cancers, especially hematological malignancies like multiple myeloma and myelodysplastic syndromes. It is also explored in the design of PROTACs (proteolysis-targeting chimeras) for degrading otherwise undruggable targets. Due to its bromo and methoxy functional groups, it serves as a versatile building block for further chemical modifications in drug discovery programs.

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Size Availability Unit Price Quantity
inventory 25mg
10-20 days ฿11,300.00
inventory 100mg
10-20 days ฿33,080.00
inventory 250mg
10-20 days ฿66,160.00
inventory 1g
10-20 days ฿198,500.00

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3-(6-Bromo-5-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon (CRBN)-based E3 ligase modulators. Its structural features enable selective binding to CRBN, facilitating the ubiquitination and subsequent degradation of disease-related proteins. This makes it valuable in developing treatments for cancers, especially hematological malignancies like multiple myeloma and myelodysplastic syndromes. It is also explored in the design of PROTA

Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon (CRBN)-based E3 ligase modulators. Its structural features enable selective binding to CRBN, facilitating the ubiquitination and subsequent degradation of disease-related proteins. This makes it valuable in developing treatments for cancers, especially hematological malignancies like multiple myeloma and myelodysplastic syndromes. It is also explored in the design of PROTACs (proteolysis-targeting chimeras) for degrading otherwise undruggable targets. Due to its bromo and methoxy functional groups, it serves as a versatile building block for further chemical modifications in drug discovery programs.

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