3-(4-Ethynyl-1-oxoisoindolin-2-yl)piperidine-2,6-dione
98%
science Other reagents with same CAS 1416990-26-5
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description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, making it valuable in developing PROTACs (proteolysis-targeting chimeras) for cancer therapy and other diseases involving protein dysregulation. It is also explored for improving pharmacokinetic properties in drug design due to its stable isoindolinone core and functional handles for chemical modification.
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