3-(1-Oxo-4-(prop-2-yn-1-ylamino)isoindolin-2-yl)piperidine-2,6-dione
97%
Reagent
Code: #130140
CAS Number
2589697-32-3
blur_circular Chemical Specifications
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Molecular Information
Weight
297.31 g/mol
Formula
C₁₆H₁₅N₃O₃
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Registry Numbers
MDL Number
MFCD32903420
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Physical Properties
Boiling Point
634.3±55.0 °C(Predicted)
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Storage & Handling
Density
1.406±0.06 g/cm3(Predicted)
Storage
Room temperature, light-proof, inert gas
description Product Description
Used primarily in pharmaceutical research, this compound functions as a cereblon E3 ligase modulator. It plays a key role in targeted protein degradation, particularly in the development of PROTACs (proteolysis-targeting chimeras). By binding to cereblon, it facilitates the ubiquitination and subsequent degradation of specific disease-related proteins. Its structure enables conjugation with other targeting ligands, making it valuable in oncology and immunomodulatory drug design. It is especially explored for its potential in treating hematological cancers and resistant tumor types.
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