Thalidomide-O-amido-C8-NH2 hydrochloride is primarily utilized in the field of medicinal chemistry and drug development. It serves as a key intermediate in the synthesis of targeted therapeutic agents, particularly in the design of proteolysis-targeting chimeras (PROTACs). These molecules are innovative tools in drug discovery, enabling the selective degradation of disease-causing proteins. Its application extends to the development of treatments for cancer, autoimmune diseases, and neurodegenerative disorders, where precise protein modulation is critical. Additionally, its structure allows for conjugation with other bioactive molecules, enhancing drug delivery and efficacy in complex biological systems.