CRBN-6-5-5-VHL

≥95%

Reagent Code: #106154
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CAS Number 2362575-45-7

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 972.20 g/mol
Formula C₅₁H₆₉N₇O₁₀S
inventory_2 Storage & Handling
Storage -20°C, dry, sealed

description Product Description

This compound is primarily utilized in the field of targeted protein degradation, particularly in the development of PROTACs (Proteolysis Targeting Chimeras). It serves as a key component in designing molecules that can selectively degrade disease-causing proteins by recruiting E3 ubiquitin ligases, such as VHL (Von Hippel-Lindau), to tag the target proteins for proteasomal destruction. Its application is significant in cancer research, where it helps in degrading oncogenic proteins that are otherwise difficult to target with traditional small-molecule inhibitors. Additionally, it is explored in neurodegenerative diseases and other conditions driven by aberrant protein accumulation. Its role in advancing precision medicine and drug discovery is notable, offering a novel approach to tackling previously undruggable targets.

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Size Availability Unit Price Quantity
inventory 5mg
10-20 days ฿36,000.00

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