CRBN-6-5-5-VHL
≥95%
Reagent
Code: #106154
CAS Number
2362575-45-7
blur_circular Chemical Specifications
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Molecular Information
Weight
972.20 g/mol
Formula
C₅₁H₆₉N₇O₁₀S
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Storage & Handling
Storage
-20°C, dry, sealed
description Product Description
This compound is primarily utilized in the field of targeted protein degradation, particularly in the development of PROTACs (Proteolysis Targeting Chimeras). It serves as a key component in designing molecules that can selectively degrade disease-causing proteins by recruiting E3 ubiquitin ligases, such as VHL (Von Hippel-Lindau), to tag the target proteins for proteasomal destruction. Its application is significant in cancer research, where it helps in degrading oncogenic proteins that are otherwise difficult to target with traditional small-molecule inhibitors. Additionally, it is explored in neurodegenerative diseases and other conditions driven by aberrant protein accumulation. Its role in advancing precision medicine and drug discovery is notable, offering a novel approach to tackling previously undruggable targets.
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