3-(5-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
98%
Reagent
Code: #220553
CAS Number
1198787-23-3
blur_circular Chemical Specifications
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Molecular Information
Weight
289.24 g/mol
Formula
C₁₃H₁₁N₃O₅
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Storage & Handling
Storage
2-8°C
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, making it valuable in developing PROTACs (proteolysis-targeting chimeras) for cancer therapy and inflammatory diseases. It is also explored for improving pharmacokinetic properties in drug design due to its stable isoindolinone core and functional handles for chemical modification.
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