Laropiprant is primarily used in combination with niacin to help reduce the flushing side effect associated with niacin therapy. Niacin, a form of vitamin B3, is often prescribed to improve cholesterol levels by increasing high-density lipoprotein (HDL) and lowering low-density lipoprotein (LDL) and triglycerides. However, niacin can cause uncomfortable flushing, which includes redness, warmth, and itching of the skin. Laropiprant works by blocking the prostaglandin D2 receptor, which is responsible for this flushing response. This combination allows patients to benefit from niacin's lipid-modifying effects while minimizing the discomfort associated with its use. It is particularly useful for individuals who require cholesterol management but are sensitive to the side effects of niacin.