Potassium trifluoro(2-fluorobiphenyl-4-yl)borate is an organoboron reagent widely used in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions for efficient carbon-carbon bond formation. It serves as a stable source for transferring the 2-fluorobiphenyl-4-yl group to aryl or heteroaryl halides, enabling the synthesis of fluorinated polyaryl compounds essential in pharmaceutical and agrochemical applications. Its excellent stability, solubility in polar organic solvents, and compatibility with mild reaction conditions make it ideal for constructing complex molecules with improved metabolic stability and binding properties in drug discovery.