Selective K Ca 1.1 channel blockers are primarily used in research and therapeutic applications targeting specific physiological processes. These blockers inhibit the K Ca 1.1 channels, which are involved in regulating smooth muscle tone, neuronal excitability, and secretion in certain cells.

In cardiovascular research, they are studied for their potential to modulate blood pressure and vascular tone by affecting smooth muscle contraction. In neurology, they are explored for their role in controlling neuronal activity, particularly in conditions like epilepsy or neuropathic pain, where abnormal neuronal firing is a concern.

Additionally, these blockers are investigated for their potential in treating overactive bladder syndrome, as they can influence the relaxation of bladder smooth muscle. Their selective action makes them valuable tools for understanding channel-specific mechanisms and developing targeted therapies.