Paspalinine is a tremorgenic mycotoxin primarily known for its biological activity in inducing tremors and neurological effects in mammals. Its main application lies in scientific research, particularly in neuroscience and toxicology, where it serves as a tool to study ion channel function and neurotransmitter release mechanisms. Due to its ability to inhibit calcium-activated potassium channels, paspalinine is used to investigate neuronal excitability and the physiological basis of tremors. It also supports studies on the mode of action of tremorgenic agents in livestock, helping to understand and mitigate mycotoxicosis in agricultural settings. Additionally, paspalinine contributes to the broader exploration of fungal metabolites with neuroactive properties, aiding in the development of pharmacological models for neurological disorders.