Tetraphenylmethane is primarily used as a building block in organic synthesis, particularly in the development of complex aromatic compounds. Its rigid, tetrahedral structure makes it valuable in the design of organic materials with specific electronic or structural properties. It serves as a precursor in the synthesis of dyes, pharmaceuticals, and specialty polymers. Due to the steric bulk provided by the four phenyl groups, it is also employed in the study of reaction mechanisms where steric hindrance plays a critical role. Additionally, derivatives of tetraphenylmethane are explored in the field of supramolecular chemistry for creating molecular cages and hosts. Its stability and lipophilic nature make it useful in the development of organic semiconductors and liquid crystals.