Hexamethylphosphoramide (HMPA) is primarily used as a polar aprotic solvent in organic synthesis. It is particularly effective in reactions involving strong bases, such as deprotonation and alkylation processes, due to its ability to stabilize anions. HMPA is often employed in the synthesis of complex organic molecules, including pharmaceuticals, where it enhances reaction rates and selectivity. Additionally, it is utilized in polymer chemistry as a solvent for polymerization reactions and in the production of high-performance materials. In some cases, HMPA is also used as a stabilizer or additive in electrochemical applications. However, its use is limited due to toxicity concerns, requiring careful handling and disposal.