GW843682X is primarily utilized in biochemical and pharmacological research as a potent and selective inhibitor of Polo-like kinase 1 (PLK1). PLK1 plays a critical role in cell cycle regulation, particularly in mitosis, making GW843682X a valuable tool for studying cell division processes. Researchers use this compound to investigate the effects of PLK1 inhibition on cancer cells, as PLK1 is often overexpressed in various tumors. By blocking PLK1 activity, GW843682X helps in understanding its role in tumor growth and progression, potentially aiding in the development of targeted cancer therapies. Additionally, it is employed in studies exploring mitotic defects, apoptosis, and the mechanisms of drug resistance in cancer cells. Its specificity and efficacy make it a key reagent in advancing knowledge in cell biology and oncology.