28-Deoxonimbolide is a bioactive limonoid derived from neem (Azadirachta indica). In agricultural applications, it acts as a natural insect antifeedant, helping protect crops by deterring pest feeding without synthetic pesticides. It supports eco-friendly pest management strategies due to its properties from neem-related compounds, with research exploring its role in sustainable farming and plant protection. Additionally, it shows medical potential, particularly in cancer research, where it inhibits cancer cell proliferation, promotes apoptosis, and exhibits anti-inflammatory effects, indicating promise for developing new treatments for chronic inflammatory and oncological diseases.