1-Boc-5,5-difluoro-3-(hydroxymethyl)piperidine
≥95%
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description Product Description
Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of fluorinated analogs of bioactive molecules. The presence of the difluoro group enhances metabolic stability and membrane permeability, making it valuable in medicinal chemistry. The Boc-protected amine allows for selective deprotection and further functionalization, enabling controlled stepwise synthesis. The hydroxymethyl group provides a handle for derivatization, such as esterification or ether formation, facilitating the construction of complex drug candidates. Commonly employed in the preparation of central nervous system agents and enzyme inhibitors where fluorine substitution improves pharmacokinetic properties.
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