AZD8186 is primarily used in the field of cancer research and treatment. It functions as a potent and selective inhibitor of PI3Kβ and PI3Kδ isoforms, which are crucial in the signaling pathways that regulate cell growth, survival, and metabolism. This makes it a valuable tool in studying the role of these pathways in various cancers, particularly those driven by PTEN loss or mutations. In preclinical studies, AZD8186 has shown promise in inhibiting tumor growth and enhancing the efficacy of other cancer therapies, such as chemotherapy and immunotherapy. Its application extends to exploring combination therapies to overcome resistance mechanisms in cancer cells, offering potential for more effective treatment strategies.