PIK-75 is primarily utilized in research settings as a potent and selective inhibitor of the PI3K p110α isoform, which plays a critical role in cell growth, proliferation, and survival. It is widely used in biochemical and cellular studies to investigate the PI3K/AKT/mTOR signaling pathway, which is often dysregulated in various cancers. By inhibiting p110α, PIK-75 helps researchers understand the role of this pathway in tumorigenesis and explore potential therapeutic strategies for cancer treatment. Additionally, it is employed in studies focusing on metabolic regulation and immune cell signaling, providing insights into the broader physiological functions of PI3K signaling. Its specificity makes it a valuable tool for dissecting the contributions of different PI3K isoforms in cellular processes.