2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one
10mM in DMSO
Reagent
Code: #204330
CAS Number
168425-64-7
blur_circular Chemical Specifications
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Molecular Information
Weight
281.32 g/mol
Formula
C₁₆H₁₅N₃O₂
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Registry Numbers
MDL Number
MFCD10568147
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Storage & Handling
Storage
-20°C
description Product Description
Used primarily in scientific research as a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K), particularly the p110δ isoform. This compound is valuable in studying signaling pathways involved in immune responses and inflammation. It has been applied in cellular assays to suppress B-cell proliferation and mast cell activation, making it a tool for investigating autoimmune diseases and allergic reactions. Additionally, due to its ability to modulate PI3K activity, it is explored in oncology research, especially in hematological malignancies where PI3K signaling is dysregulated. Its selectivity allows for targeted pathway inhibition with reduced off-target effects in experimental models.
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