PF-05381941 is primarily used in research settings as a potent and selective inhibitor of the enzyme PI3Kγ (phosphoinositide 3-kinase gamma). Its application is significant in studying inflammatory and autoimmune diseases, as PI3Kγ plays a crucial role in immune cell signaling and function. Researchers utilize this compound to investigate the pathways involved in chronic inflammation, rheumatoid arthritis, and other immune-related disorders. Additionally, it aids in exploring potential therapeutic strategies targeting PI3Kγ to modulate immune responses. Its selectivity makes it a valuable tool for understanding the specific contributions of PI3Kγ in cellular processes and disease mechanisms.