Harmine is primarily used in research settings for its ability to inhibit monoamine oxidase (MAO), making it valuable in studies related to neurodegenerative diseases like Parkinson's and Alzheimer's. It is also explored for its potential antidepressant and anxiolytic effects due to its interaction with serotonin receptors. Additionally, harmine has shown potential in diabetes research by promoting pancreatic beta-cell regeneration, which may help stimulate insulin production and increase insulin sensitivity. In ethnopharmacology, harmine is studied for its role in traditional ayahuasca brews, where it acts as a psychoactive compound. Furthermore, it has shown promise in cancer research for its anti-proliferative properties, particularly in inhibiting the growth of certain tumor cells. Its application in regenerative medicine is also being investigated, as it may promote the differentiation of stem cells.