Securinine is primarily used in medical research and pharmaceutical applications due to its central nervous system (CNS) stimulating properties. It acts as a GABA antagonist, which enhances neuronal excitability and can improve nerve signal transmission. This makes it a candidate for studying neurodegenerative conditions such as multiple sclerosis and peripheral nervous system disorders. It has been investigated for its potential to reverse neuromuscular blockade, offering possible use in anesthesia recovery. Additionally, securinine exhibits neuroprotective and cognitive-enhancing effects in preclinical models, suggesting relevance in treating cognitive impairments or nerve injury. In traditional medicine contexts, it has been explored as a treatment for paralysis and related neuromuscular conditions. Recent studies also indicate antimicrobial and anticancer activities, broadening its scope in drug development. However, its clinical use remains limited due to toxicity concerns and narrow therapeutic window.