Used in agricultural research as a natural insecticidal compound, Rhodojaponin II shows strong antifeedant and growth inhibitory effects against various insect pests. It is studied for its potential in developing botanical pesticides due to its ability to disrupt insect feeding behavior and reproduction. The compound exhibits activity against lepidopteran larvae, making it valuable in exploring eco-friendly pest control methods. Additionally, it has drawn interest in biochemical studies for understanding plant-insect interactions and co-evolution of defense mechanisms in plants.