Rutaecarpine is primarily studied for its cardiovascular and anti-inflammatory effects. It has shown potential in promoting vasodilation, which may help in lowering blood pressure. Research indicates it can activate the transient receptor potential vanilloid type 1 (TRPV1) channel, leading to the release of calcitonin gene-related peptide (CGRP), a potent vasodilator. It is also investigated for its antiplatelet and antithrombotic properties, suggesting possible use in preventing blood clots. Additionally, rutaecarpine exhibits anti-inflammatory and analgesic activities by modulating pathways such as NF-κB and COX-2. Some studies explore its role in metabolic health, including effects on lipid metabolism and insulin sensitivity, pointing to potential benefits in managing metabolic syndrome. Due to its ability to cross the blood-brain barrier, it is also considered in neuroprotection research, though this area remains early-stage. Most applications are still within preclinical research, and human studies are limited.