Rutaecarpine is primarily studied for its cardiovascular effects, particularly its ability to promote vasodilation and lower blood pressure. It activates transient receptor potential vanilloid 1 (TRPV1) channels, leading to the release of calcitonin gene-related peptide (CGRP), a potent vasodilator. This mechanism makes it a subject of interest in research on hypertension and circulatory disorders. It also exhibits anti-inflammatory and antioxidant properties, suggesting potential use in managing inflammatory conditions and oxidative stress-related diseases. Some studies explore its role in improving metabolic health, including lipid metabolism and insulin sensitivity, indicating possible applications in metabolic syndrome and type 2 diabetes. In traditional medicine contexts, extracts containing rutaecarpine have been used to support cardiovascular and digestive health, though modern therapeutic use remains largely in the research phase. Its ability to modulate cytochrome P450 enzymes also raises interest in drug interaction studies, especially in herbal formulation development.